Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of AML1/Runx1 in the pathogenesis of hematological malignancies

1 Oct 2003

Abstract excerpt

AML1/Runx1, originally identified as a gene located at the breakpoint of the t(8;21) translocation, encodes one of the two subunits forming a heterodimeric transcription factor. AML1 contains a highly evolutionally conserved domain called the Runt domain, responsible for both DNA binding and heterodimerization with the partner protein, CBFbeta. AML1 is widely expressed in all hematopoietic lineages, and regulates...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Lymphoblastic Leukemia research
Share to Acute Myeloid Leukemia Research
Share to Genomics and Chromatin Dynamics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 14556655
DOI: 10.1111/j.1349-7006.2003.tb01364.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of AML1/Runx1 in the pathogenesis of hematological malignanciesPMID 14556655Read ↗

The role of a Runt domain transcription factor AML1/RUNX1 in leukemogenesis and its clinical implicationsSemantic proximity Read ↗

Role of RUNX1 in hematological malignanciesSemantic proximity Read ↗

Runx1/AML-1 Ranks as a Master Regulator of Adult HematopoiesisSemantic proximity Read ↗

The Clinical, Molecular, and Mechanistic Basis of RUNX1 Mutations Identified in Hematological Malignancies.Semantic proximity Read ↗

AML1, AML2, and AML3, the Human Members of the runt domain Gene-Family: cDNA Structure, Expression, and Chromosomal LocalizationSemantic proximity Read ↗

Targeting RUNX1 in acute myeloid leukemia: preclinical innovations and therapeutic implications.Semantic proximity Read ↗

New mechanisms of AML1 gene alteration in hematological malignancies.Semantic proximity Read ↗

Normal and transforming functions of RUNX1: A perspectiveSemantic proximity Read ↗

RUNX1 and cancerSemantic proximity Read ↗

RUNX1 and RUNX1-ETO: roles in hematopoiesis and leukemogenesisSemantic proximity Read ↗

Proleukemic RUNX1 and CBFbeta mutations in the pathogenesis of acute leukemia.Semantic proximity Read ↗

Point mutations in the RUNX1/AML1 gene: another actor in RUNX leukemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.