The Role of RUNX1 in NF1-Related Tumors and Blood Disorders.

Abstract excerpt

Neurofibromatosis type 1 (NF1) is an autosomal dominant disorder. NF1 patients are predisposed to formation of several type solid tumors as well as to juvenile myelomonocytic leukemia. Loss of NF1 results in dysregulation of MAPK, PI3K and other signaling cascades, to promote cell proliferation and to inhibit cell apoptosis. The RUNX1 gene is associated with stem cell function in many tissues, and plays a key...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Core Binding Factor Alpha 2 Subunit
• Share to Hematologic Diseases
• Share to Mutation