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Article

MGMT CpG island is invariably methylated in adult astrocytic and oligodendroglial tumors with IDH1 or IDH2 mutations.

International journal of cancer - 1 Sept 2012

Mulholland Shani, Pearson Danita M, Hamoudi Rifat A, Malley Deborah S, Smith Caroline M, Weaver Jamie M J, Jones David T W, Kocialkowski Sylvia, Bäcklund L Magnus, Collins V Peter, Ichimura Koichi

Abstract excerpt

We have previously identified a region containing 16 CpGs within the MGMT CpG islands which is critical for the transcriptional control of MGMT (Malley, Acta Neuropathol 2011). To investigate the patterns and incidence of MGMT methylation in astrocytic and oligodendroglial tumors, we quantitatively assessed methylation at these 16 CpGs using bisulfite modification followed by pyrosequencing of 362 gliomas not...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22020830
DOI: 10.1002/ijc.26499

Genes

MGMT
IDH1
IDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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