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Unveiling hierarchy and spatial distribution of O6-methylguanine-DNA methyltransferase promoter methylation in World Health Organization grade 2-3 gliomas.

Cancer science - 1 Oct 2024

Li Mingxiao, Liu Jiang, Weng Jiancong, Dong Gehong, Chen Xuzhu, Cui Yong, Ren Xiaohui, Shen Shaoping, Jiang Haihui, Zhang Xiaokang, Zhao Xuzhe, Li Ming, Wang Xijie, Ren Hongxiang, Li Qiang, Zhang Yulian, Cheng Quan, Yu Yanbing, Lin Song

Abstract excerpt

This study investigated the role of O6-methylguanine-DNA methyltransferase promoter (MGMTp) methylation hierarchy and heterogeneity in grade 2-3 gliomas, focusing on variations in chemotherapy benefits and resection dependency. A cohort of 668 newly diagnosed grade 2-3 gliomas, with comprehensive clinical, radiological, and molecular data, formed the basis of this analysis. The extent of resection was categorized...

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Astrocytoma
DNA Modification Methylases
DNA Repair Enzymes
Isocitrate Dehydrogenase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasm Grading

O(6)-Methylguanine-DNA Methyltransferase

Oligodendroglioma

World Health Organization

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Open in PubMed Open full text

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PMID: 39101880
DOI: 10.1111/cas.16268
PMCID: PMC11447971

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