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Article

Differential IL-21 signaling in APCs leads to disparate Th17 differentiation in diabetes-susceptible NOD and diabetes-resistant NOD.Idd3 mice.

The Journal of clinical investigation - 1 Nov 2011

Liu Sue M, Lee David H, Sullivan Jenna M, Chung Denise, Jäger Anneli, Shum Bennett O V, Sarvetnick Nora E, Anderson Ana C, Kuchroo Vijay K

Abstract excerpt

Type 1 diabetes (T1D) is an autoimmune disease that shows familial aggregation in humans and likely has genetic determinants. Disease linkage studies have revealed many susceptibility loci for T1D in mice and humans. The mouse T1D susceptibility locus insulin-dependent diabetes susceptibility 3 (Idd3), which has a homologous genetic interval in humans, encodes cytokine genes Il2 and Il21 and regulates diabetes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22019586
DOI: 10.1172/JCI46187
PMCID: PMC3204832

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