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Article

Loss of parity between IL-2 and IL-21 in the NOD Idd3 locus.

Proceedings of the National Academy of Sciences of the United States of America - 17 Nov 2009

McGuire Helen M, Vogelzang Alexis, Hill Natasha, Flodström-Tullberg Malin, Sprent Jonathan, King Cecile

Abstract excerpt

IL-2 and IL-21 are two cytokines with great potential to affect autoimmune infiltration of nonlymphoid tissue, and are contained within the strongest non-MHC-linked locus for type 1 diabetes (T1D) susceptibility on the nonobese diabetic (NOD) mouse (Idd3). IL-21 is necessary for the development of diabetes in the NOD mouse, but a number of important studies argue that decreased expression of IL-2 explains Idd3....

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Identifiers

PMID: 19880748
DOI: 10.1073/pnas.0903561106
PMCID: PMC2780811

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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