Article
Genome-wide analysis of allelic expression imbalance in human primary cells by high-throughput transcriptome resequencing.
Human molecular genetics - 1 Jan 2010
Heap Graham A, Yang Jennie H M, Downes Kate, Healy Barry C, Hunt Karen A, Bockett Nicholas, Franke Lude, Dubois Patrick C, Mein Charles A, Dobson Richard J, Albert Thomas J, Rodesch Matthew J, Clayton David G, Todd John A, van Heel David A, Plagnol Vincent
Abstract excerpt
Many disease-associated variants identified by genome-wide association (GWA) studies are expected to regulate gene expression. Allele-specific expression (ASE) quantifies transcription from both haplotypes using individuals heterozygous at tested SNPs. We performed deep human transcriptome-wide resequencing (RNA-seq) for ASE analysis and expression quantitative trait locus discovery. We resequenced double...
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