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Article

Recommendations for Accurate Resolution of Gene and Isoform Allele-Specific Expression in RNA-Seq Data.

PloS one - 1 Jan 2015

Wood David L A, Nones Katia, Steptoe Anita, Christ Angelika, Harliwong Ivon, Newell Felicity, Bruxner Timothy J C, Miller David, Cloonan Nicole, Grimmond Sean M

Abstract excerpt

Genetic variation modulates gene expression transcriptionally or post-transcriptionally, and can profoundly alter an individual's phenotype. Measuring allelic differential expression at heterozygous loci within an individual, a phenomenon called allele-specific expression (ASE), can assist in identifying such factors. Massively parallel DNA and RNA sequencing and advances in bioinformatic methodologies provide an...

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PMID: 25965996
DOI: 10.1371/journal.pone.0126911
PMCID: PMC4428808

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UBD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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