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Article

Chronic infusion of SOD1G93A astrocyte-secreted factors induces spinal motoneuron degeneration and neuromuscular dysfunction in healthy rats.

Journal of cellular physiology - 1 Oct 2017

Ramírez-Jarquín Uri N, Rojas Fabiola, van Zundert Brigitte, Tapia Ricardo

Abstract excerpt

Amyotrophic lateral sclerosis is a fatal neurodegenerative disease and studies in vitro show that motoneuron degeneration is triggered by non-cell-autonomous mechanisms. However, whether soluble toxic factor(s) released by mutant superoxide dismutase 1 (SOD1) expressing astrocytes induces death of motoneurons and leads to motor dysfunction in vivo is not known. To directly test this, healthy adult rats were...

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Identifiers

PMID: 28128448
DOI: 10.1002/jcp.25827

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SOD1

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