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Article

Phenotypic transition of microglia into astrocyte-like cells associated with disease onset in a model of inherited ALS

1 Jan 2013

Abstract excerpt

Microglia and reactive astrocytes accumulate in the spinal cord of rats expressing the Amyotrophic lateral sclerosis (ALS)-linked SOD1 (G93A) mutation. We previously reported that the rapid progression of paralysis in ALS rats is associated with the appearance of proliferative astrocyte-like cells that surround motor neurons. These cells, designated as Aberrant Astrocytes (AbA cells) because of their atypical...

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PMID: 24399933
DOI: 10.3389/fncel.2013.00274

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