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Article

Isolation and characterization of a Chinese hamster ovary cell line deficient in fatty alcohol:NAD+ oxidoreductase activity.

Proceedings of the National Academy of Sciences of the United States of America - 1 Aug 1990

James P F, Rizzo W B, Lee J, Zoeller R A

Abstract excerpt

We have isolated a mutant Chinese hamster ovary cell line that is defective in long-chain fatty alcohol oxidation. The ability of the mutant cells to convert labeled hexadecanol to the corresponding fatty acid in vivo was reduced to 5% of the parent strain. Whole-cell homogenates from the mutant strain, FAA.1, were deficient in long-chain fatty alcohol:NAD+ oxidoreductase (FAO; EC 1.1.1.192) activity, which...

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Identifiers

PMID: 2201021
DOI: 10.1073/pnas.87.16.6102
PMCID: PMC54480

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