Article
Deep congenic analysis identifies many strong, context-dependent QTLs, one of which, Slc35b4, regulates obesity and glucose homeostasis.
Genome research - 1 Jul 2011
Yazbek Soha N, Buchner David A, Geisinger Jonathan M, Burrage Lindsay C, Spiezio Sabrina H, Zentner Gabriel E, Hsieh Chang-Wen, Scacheri Peter C, Croniger Colleen M, Nadeau Joseph H
Abstract excerpt
Although central to many studies of phenotypic variation and disease susceptibility, characterizing the genetic architecture of complex traits has been unexpectedly difficult. For example, most of the susceptibility genes that contribute to highly heritable conditions such as obesity and type 2 diabetes (T2D) remain to be identified despite intensive study. We took advantage of mouse models of diet-induced...
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