Article
Omeprazole limited sampling strategies to predict area under the concentration-time curve ratios: implications for cytochrome P450 2C19 and 3A phenotyping.
European journal of clinical pharmacology - 1 Apr 2012
Lawson Eileen B, Wu Jerry C, Baldwin R Michael, Ingelman-Sundberg Magnus, Rosenborg Staffan, Yim Dong-Seok, Yin Ophelia Q P, Capparelli Edmund V, Ma Joseph D
Abstract excerpt
PURPOSE: To develop a limited sampling strategy (LSS) to predict area under the concentration-time curve (AUC) ratios of omeprazole (AUC(OPZ)) to its metabolites 5-hydroxyomeprazole (AUC(5OH)) and omeprazole sulfone (AUC(SUL)) as phenotyping parameters for cytochrome P450 (CYP) 2C19 and 3A. METHODS: Data were obtained from 37 (4 women) Caucasian, Chinese, and Korean healthy adults from three published studies....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.