Article
Limited sampling strategy of partial area under the concentration-time curves to estimate midazolam systemic clearance for cytochrome P450 3A phenotyping.
Therapeutic drug monitoring - 1 Feb 2015
Masters Joanna C, Harano Denise M, Greenberg Howard E, Tsunoda Shirley M, Jang In-Jin, Ma Joseph D
Abstract excerpt
OBJECTIVE: Intravenous (IV) midazolam is the preferred cytochrome P450 (CYP) 3A probe for phenotyping, with systemic clearance (CL) estimating hepatic CYP3A activity. A limited sampling strategy was conducted to determine whether partial area under the concentration-time curves (AUCs) could reliably estimate midazolam systemic CL during conditions of CYP3A baseline activity, inhibition, and induction/activation....
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