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Article

Estimation of the area under the concentration-time curve of racemic lansoprazole by using limited plasma concentration of lansoprazole enantiomers.

European journal of clinical pharmacology - 1 May 2008

Niioka Takenori, Miura Masatomo, Uno Tsukasa, Yasui-Furukori Norio, Hayakari Makoto, Tateishi Tomonori, Suzuki Toshio

Abstract excerpt

OBJECTIVE: The purpose of this study was to identify the common time point that gives plasma concentrations of lansoprazole enantiomers that adequately reflect the AUC of racemic lansoprazole. METHODS: A randomized, double-blind, placebo-controlled, crossover study in three phases was conducted at intervals of 2 weeks. Eighteen healthy Japanese volunteers, including three CYP2C19 genotype groups, took a single...

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PMID: 18224311
DOI: 10.1007/s00228-007-0455-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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