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Article

Limited sampling strategy to predict AUC of the CYP3A phenotyping probe midazolam in adults: application to various assay techniques.

Journal of clinical pharmacology - 1 Apr 2002

Kim Jooran S, Nafziger Anne N, Tsunoda Shirley M, Choo Edna E, Streetman Daniel S, Kashuba Angela D M, Kulawy Robert W, Beck Debra J, Rocci Mario L, Wilkinson Grant R, Greenblatt David J, Bertino Joseph S

Abstract excerpt

Midazolam clearance is used to phenotype hepatic CYP3A activity but requires multiple plasma samples following a single intravenous dose. The authors evaluated the use of a limited sampling scheme, using different assay techniques to determine the reproducibility of such a strategy in estimating midazolam AUC. Seventy-three healthy adults received midazolam as a single intravenous bolus dose. At least eight...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 11936561

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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