Limited sampling strategy of S-warfarin concentrations, but not warfarin S/R ratios, accurately predicts S-warfarin AUC during baseline and inhibition in CYP2C9 extensive metabolizers.

Abstract excerpt

S-warfarin area under the concentration-time curve (AUC(0- infinity )) and clearance are used as measures of cytochrome p450 (CYP) 2C9 activity. In addition, warfarin S/R ratios are used to assess CYP2C9 activity. The determination of S-warfarin AUC(0- infinity ) requires multiple blood samples. Limited sampling strategy (LSS) is a validated technique that estimates AUC(0- infinity ) using limited blood samples....

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