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Article

Clinical usefulness of limited sampling strategies for estimating AUC of proton pump inhibitors.

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan - 1 Mar 2011

Niioka Takenori

Abstract excerpt

Cytochrome P450 (CYP) 2C19 (CYP2C19) genotype is regarded as a useful tool to predict area under the blood concentration-time curve (AUC) of proton pump inhibitors (PPIs). In our results, however, CYP2C19 genotypes had no influence on AUC of all PPIs during fluvoxamine treatment. These findings suggest that CYP2C19 genotyping is not always a good indicator for estimating AUC of PPIs. Limited sampling strategies...

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PMID: 21372537
DOI: 10.1248/yakushi.131.407

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