Article
Evaluation of Omeprazole Limited Sampling Strategies to Estimate Constitutive Cytochrome P450 2C19 Activity in Healthy Adults.
Therapeutic drug monitoring - 1 Dec 2018
Lin Swan, Nikanjam Mina, Capparelli Edmund V, Allegrini Alessandro, Pavone Daniele, Yim Dong-Seok, Hammami Muhammad M, Bertino Joseph S, Nafziger Anne N, Park Yoo-Sin, Kang Ju-Seop, Yin Ophelia Q, Ma Joseph D
Abstract excerpt
BACKGROUND: Limited sampling strategy (LSS) is a validated method to estimate pharmacokinetic (PK) parameters from a reduced number of samples. Omeprazole is used to phenotype in vivo cytochrome P450 (CYP) 2C19 activity. This study examined an LSS using 2 estimation methods to determine apparent oral clearance (CL/F) and thus CYP2C19 activity. METHODS: Data from 7 previously published studies included healthy...
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