Article
Evaluation of partial area under the concentration time curve to estimate midazolam apparent oral clearance for cytochrome P450 3A phenotyping.
Drug metabolism and drug interactions - 1 Jan 2013
Tai Wei, Gong Sheryl L, Tsunoda Shirley M, Greenberg Howard E, Gorski J Christopher, Penzak Scott R, Stoch S Aubrey, Ma Joseph D
Abstract excerpt
BACKGROUND: Midazolam apparent oral clearance (CLORAL) is used to estimate intestinal and hepatic cytochrome P450 (CYP) 3A activity. A limited sampling approach was performed to access a midazolam partial area under the concentration time curve (AUC) to estimate CLORAL. METHODS: Midazolam plasma concentrations from healthy adults were obtained during CYP3A baseline (n=116), inhibition (n=75), and induction or...
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