Article
S-Warfarin Limited Sampling Models to Estimate Area Under the Concentration Versus Time Curve for Cytochrome P450 2C9 Baseline Activity and After Induction.
Therapeutic drug monitoring - 1 Jun 2016
Chang Andrew T, Bertino Joseph S, Nafziger Anne N, Kashuba Angela D M, Turpault Sandrine, Lewis Lionel D, Ma Joseph D
Abstract excerpt
BACKGROUND: Phenotyping cytochrome P450 (CYP) 2C9 activity using S-warfarin has routinely required extensive blood sampling over at least 96 hours after dose to estimate the area under the concentration time curve from zero to infinity (AUC). Alternatively, S-warfarin limited sampling models (LSMs) using one or 2 concentration timepoints have been proposed to estimate AUC. This study evaluated whether S-warfarin...
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