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Article

S-warfarin limited sampling strategy with a population pharmacokinetic approach to estimate exposure and cytochrome P450 (CYP) 2C9 activity in healthy adults.

European journal of clinical pharmacology - 1 Sept 2021

Tran Lana, Nikanjam Mina, Capparelli Edmund V, Bertino Joseph S, Nafziger Anne N, Kashuba Angela D M, Turpault Sandrine, Ma Joseph D

Abstract excerpt

PURPOSE: S-warfarin is used to phenotype cytochrome P450 (CYP) 2C9 activity. This study evaluated S-warfarin limited sampling strategy with a population pharmacokinetic (PK) approach to estimate CYP2C9 activity in healthy adults. METHODS: In 6 previously published studies, a single oral dose of warfarin 10 mg was administered alone or with a CYP2C9 inducer to 100 healthy adults. S-warfarin concentrations were...

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Area Under Curve
Cytochrome P-450 CYP2C9
Drug Combinations
Healthy Volunteers
Lopinavir

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Metabolic Clearance Rate

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PMID: 33754183
DOI: 10.1007/s00228-021-03123-y

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