Article
Microbial cytochromes P450: biodiversity and biotechnology. Where do cytochromes P450 come from, what do they do and what can they do for us?
Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 19 Feb 2013
Kelly Steven L, Kelly Diane E
Abstract excerpt
The first eukaryote genome revealed three yeast cytochromes P450 (CYPs), hence the subsequent realization that some microbial fungal genomes encode these proteins in 1 per cent or more of all genes (greater than 100) has been surprising. They are unique biocatalysts undertaking a wide array of stereo- and regio-specific reactions and so hold promise in many applications. Based on ancestral activities that...
Topics
- Antifungal Agents
- Bacteria
- Biological Products
- Biotechnology
- Cytochrome P-450 Enzyme System
- Drug Resistance, Fungal
- Electrons
- Evolution, Molecular
- Fungi
- Humans
- Mutation
- Mycoses
- Oxygen
- Sterols