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Article

A novel semi-biosynthetic route for artemisinin production using engineered substrate-promiscuous P450(BM3).

ACS chemical biology - 17 Apr 2009

Dietrich Jeffrey A, Yoshikuni Yasuo, Fisher Karl J, Woolard Frank X, Ockey Denise, McPhee Derek J, Renninger Neil S, Chang Michelle C Y, Baker David, Keasling Jay D

Abstract excerpt

Production of fine chemicals from heterologous pathways in microbial hosts is frequently hindered by insufficient knowledge of the native metabolic pathway and its cognate enzymes; often the pathway is unresolved, and the enzymes lack detailed characterization. An alternative paradigm to using native pathways is de novo pathway design using well-characterized, substrate-promiscuous enzymes. We demonstrate this...

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PMID: 19271725
DOI: 10.1021/cb900006h

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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