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Characterization of diverse natural variants of CYP102A1 found within a species of Bacillus megaterium

28 Mar 2011

Abstract excerpt

An extreme diversity of substrates and catalytic reactions of cytochrome P450 (P450) enzymes is considered to be the consequence of evolutionary adaptation driven by different metabolic or environmental demands. Here we report the presence of numerous natural variants of P450 BM3 (CYP102A1) within a species of Bacillus megaterium. Extensive amino acid substitutions (up to 5% of the total 1049 amino acid residues)...

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PMID: 21906327
DOI: 10.1186/2191-0855-1-1

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