Calibrating genome wide significance by minor allele frequency across three major populations.

Abstract excerpt

Conventional genome-wide association study (GWAS) thresholds, notably 5 × 10⁻⁸, were established under assumptions that may not hold across diverse populations and whole-genome sequencing (WGS) analyses. Given the complex linkage disequilibrium structure of the human genome, a single fixed threshold risks inadequate type I error control. Here, we sought to derive minor allele frequency (MAF)-specific,...

Topics

• Humans
• Genome-Wide Association Study
• Gene Frequency
• Linkage Disequilibrium
• Genome, Human
• Asian People