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Article

Efficient calculation of empirical P-values for genome-wide linkage analysis through weighted permutation.

Behavior genetics - 1 Jan 2009

Medland Sarah E, Schmitt James E, Webb Bradley T, Kuo Po-Hsiu, Neale Michael C

Abstract excerpt

Linkage analysis in multivariate or longitudinal context presents both statistical and computational challenges. The permutation test can be used to avoid some of the statistical challenges, but it substantially adds to the computational burden. Utilizing the distributional dependencies between p (defined as the proportion of alleles at a locus that are identical by descent (IBD) for a pairs of relatives, at a...

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Identifiers

PMID: 18810631
DOI: 10.1007/s10519-008-9229-9
PMCID: PMC4010137

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