Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ras-independent growth factor signaling by transcription factor tyrosine phosphorylation.

Science (New York, N.Y.) - 24 Sept 1993

Silvennoinen O, Schindler C, Schlessinger J, Levy D E

Abstract excerpt

Interferons induce transcriptional activation through tyrosine phosphorylation of the latent, cytoplasmic transcription factor interferon-stimulated gene factor-3 (ISGF-3). Growth factors and cytokines were found to use a similar pathway: The 91-kilodalton subunit of ISGF-3 was activated and tyrosine phosphorylated in response to epidermal growth factor (EGF), platelet-derived growth factor, and colony...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Cell Line
Share to DNA-Binding Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, ras

Share to Molecular Sequence Data

Share to Mutation

Share to Phosphorylation

Source

Identifiers

PMID: 8378775
DOI: 10.1126/science.8378775

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ras-independent growth factor signaling by transcription factor tyrosine phosphorylation.PMID 8378775Read ↗

Transcription factor ISGF-3 formation requires phosphorylated Stat91 protein, but Stat113 protein is phosphorylated independently of Stat91 protein.Semantic proximity Read ↗

Proteins of transcription factor ISGF-3: one gene encodes the 91-and 84-kDa ISGF-3 proteins that are activated by interferon alpha.Semantic proximity Read ↗

Essential role of interferon regulatory factor 3 in direct activation of RANTES chemokine transcription.Semantic proximity Read ↗

Increased tyrosine phosphorylation in ras transformed fibroblasts occurs prior to manifestation of the transformed phenotype.Semantic proximity Read ↗

Direct Association of STAT3 with the IFNAR-1 Chain of the Human Type I Interferon ReceptorSemantic proximity Read ↗

Tyrosine phosphorylation acts as a molecular switch to full-scale activation of the eIF2alpha RNA-dependent protein kinase.Semantic proximity Read ↗

Interferon regulatory factor subcellular localization is determined by a bipartite nuclear localization signal in the DNA-binding domain and interaction with cytoplasmic retention factorsSemantic proximity Read ↗

p38 MAP kinase is required for STAT1 serine phosphorylation and transcriptional activation induced by interferons.Semantic proximity Read ↗

Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase.Semantic proximity Read ↗

Rapid estrogen-induced phosphorylation of the SRC-3 coactivator occurs in an extranuclear complex containing estrogen receptor.Semantic proximity Read ↗

Mitogen-activated 3p kinase is active in the nucleus.Semantic proximity Read ↗

Mechanism of interferon action: evidence for intermolecular autophosphorylation and autoactivation of the interferon-induced, RNA-dependent protein kinase PKR.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.