Ras-independent growth factor signaling by transcription factor tyrosine phosphorylation.

doi:10.1126/science.8378775

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Article

Ras-independent growth factor signaling by transcription factor tyrosine phosphorylation.

Science (New York, N.Y.) - 24 Sept 1993

Silvennoinen O, Schindler C, Schlessinger J, Levy D E

Abstract excerpt

Interferons induce transcriptional activation through tyrosine phosphorylation of the latent, cytoplasmic transcription factor interferon-stimulated gene factor-3 (ISGF-3). Growth factors and cytokines were found to use a similar pathway: The 91-kilodalton subunit of ISGF-3 was activated and tyro...

Topics

3T3 Cells
Animals
Base Sequence
Cell Line
DNA-Binding Proteins
Epidermal Growth Factor
ErbB Receptors
Genes, ras
Growth Substances
Humans
Interferon-Stimulated Gene Factor 3
Interferon-Stimulated Gene Factor 3, gamma Subunit

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Macrophage Colony-Stimulating Factor

Mice

Molecular Sequence Data

Mutation

Phosphorylation

Platelet-Derived Growth Factor

Source

Open in PubMed

Identifiers

PMID: 8378775
DOI: 10.1126/science.8378775

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8378775-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Ras-independent growth factor signaling by transcription factor tyrosine phosphorylation.PMID 8378775Read ↗

Transcription factor ISGF-3 formation requires phosphorylated Stat91 protein, but Stat113 protein is phosphorylated independently of Stat91 protein.Semantic proximity Read ↗

Proteins of transcription factor ISGF-3: one gene encodes the 91-and 84-kDa ISGF-3 proteins that are activated by interferon alpha.Semantic proximity Read ↗

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