Article
Neoplastic transformation of normal rat embryo fibroblasts by a mutated p53 and an activated ras oncogene induces parathyroid hormone-related peptide gene expression and causes hypercalcemia in nude mice.
The Journal of biological chemistry - 29 Dec 1995
Motokura T, Endo K, Kumaki K, Ogata E, Ikeda K
Abstract excerpt
Parathyroid hormone-related peptide (PTHRP) is a 141-amino acid protein identified in various carcinomas associated with humoral hypercalcemia of malignancy (HHM). Although the causal role of PTHRP in HHM syndrome has been established, the molecular and cellular mechanism by which PTHRP gene is o...
Topics
- Animals
- Cell Transformation, Neoplastic
- Embryo, Mammalian
- Fibroblasts
- Genes, ras
- Hypercalcemia
- Mice
- Mice, Nude
- Mutation
- Neoplasm Proteins
- Parathyroid Hormone-Related Protein