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Article

Constraints on amino acid substitutions in the N-terminal helix of cytochrome c explored by random mutagenesis.

Biochemistry - 3 Sept 1991

Auld D S, Pielak G J

Abstract excerpt

The interaction of the N- and C-terminal helices is a hallmark of the cytochrome c family. Oligodeoxyribonucleotide-directed random mutagenesis within the gene encoding the C102T protein variant of Saccharomyces cerevisiae iso-1-cytochrome c was used to generate a library of mutations at the evolutionary invariant residues Gly-6 and Phe-10 in the N-terminal helix. Transformation of this library (contained on a...

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PMID: 1653604
DOI: 10.1021/bi00099a028

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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