Antifungal Tc17 cells are durable and stable, persisting as long-lasting vaccine memory without plasticity towards IFNγ cells

Abstract excerpt

Our understanding of persistence and plasticity of IL-17A + memory T cells is clouded by conflicting results in models analyzing T helper 17 cells.We studied memory IL-17A + CD8 + T-cell (Tc17) homeostasis, persistence and plasticity during fungal vaccine immunity.We report that vaccine-induced memory Tc17 cells persist with high fidelity to the type 17 phenotype.Tc17 cells persisted durably for a year as...

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