Article
Exposure of bipartite hydrophobic signal triggers nuclear quality control of Ndc10 at the endoplasmic reticulum/nuclear envelope.
Molecular biology of the cell - 1 Dec 2011
Furth Noa, Gertman Or, Shiber Ayala, Alfassy Omri S, Cohen Itamar, Rosenberg Masha M, Doron Nurit Kleinberger, Friedler Assaf, Ravid Tommer
Abstract excerpt
Proper functioning of the protein-folding quality control network depends on the network's ability to discern diverse structural perturbations to the native states of its protein substrates. Despite the centrality of the detection of misfolded states to cell home-ostasis, very little is known about the exact sequence and structural features that mark a protein as being misfolded. To investigate these features, we...
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