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Article

Membrane and soluble substrates of the Doa10 ubiquitin ligase are degraded by distinct pathways.

The EMBO journal - 8 Feb 2006

Ravid Tommer, Kreft Stefan G, Hochstrasser Mark

Abstract excerpt

The yeast Doa10 ubiquitin (Ub) ligase resides in the endoplasmic reticulum (ER)/nuclear envelope (NE), where it functions in ER-associated degradation (ERAD). Doa10 substrates include non-ER proteins such as the transcription factor Mat alpha2. Here, we expand the range of Doa10 substrates to include a defective kinetochore component, a mutant NE membrane protein, and a substrate-regulated human ER enzyme. For...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16437165
DOI: 10.1038/sj.emboj.7600946
PMCID: PMC1383530

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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