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Article

Degradation-mediated protein quality control in the nucleus.

Cell - 25 Mar 2005

Gardner Richard G, Nelson Zara W, Gottschling Daniel E

Abstract excerpt

Protein quality control degradation systems rid the cell of aberrant proteins, preventing detrimental effects on normal cellular function. Although such systems have been identified in most subcellular compartments, none have been found in the nucleus. Here, we report the discovery of such a system in Saccharomyces cerevisiae. It is defined by San1p, a ubiquitin-protein ligase that, in conjunction with the...

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Identifiers

PMID: 15797381
DOI: 10.1016/j.cell.2005.01.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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