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Article

Implications for proteasome nuclear localization revealed by the structure of the nuclear proteasome tether protein Cut8.

Proceedings of the National Academy of Sciences of the United States of America - 11 Oct 2011

Takeda Kojiro, Tonthat Nam K, Glover Tiffany, Xu Weijun, Koonin Eugene V, Yanagida Mitsuhiro, Schumacher Maria A

Abstract excerpt

Degradation of nuclear proteins by the 26S proteasome is essential for cell viability. In yeast, the nuclear envelope protein Cut8 mediates nuclear proteasomal sequestration by an uncharacterized mechanism. Here we describe structures of Schizosaccharomyces pombe Cut8, which shows that it contain...

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Identifiers

PMID: 21976488
DOI: 10.1073/pnas.1103617108
PMCID: PMC3193221

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21976488-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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