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Article

The Notch-regulated ankyrin repeat protein is required for proper anterior-posterior somite patterning in mice.

Genesis (New York, N.Y. : 2000) - 1 Apr 2012

Krebs Luke T, Bradley Cara K, Norton Christine R, Xu Jingxia, Oram Kathleen F, Starling Christa, Deftos Michael L, Bevan Michael J, Gridley Thomas

Abstract excerpt

The Notch-regulated ankyrin repeat protein (Nrarp) is a component of a negative feedback system that attenuates Notch pathway-mediated signaling. In vertebrates, the timing and spacing of formation of the mesodermal somites are controlled by a molecular oscillator termed the segmentation clock. Somites are also patterned along the rostral-caudal axis of the embryo. Here, we demonstrate that Nrarp-deficient...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21998026
DOI: 10.1002/dvg.20813
PMCID: PMC3314717

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The Notch-regulated ankyrin repeat protein is required for proper anterior-posterior somite patterning in mice.PMID 21998026Read ↗

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