Article
Tbx24, encoding a T-box protein, is mutated in the zebrafish somite-segmentation mutant fused somites.
Nature genetics - 1 Jun 2002
Nikaido Masataka, Kawakami Atsushi, Sawada Atsushi, Furutani-Seiki Makoto, Takeda Hiroyuki, Araki Kazuo
Abstract excerpt
Somites are fundamental structures within the paraxial mesoderm of the vertebrate embryo that give rise to the vertebrae and muscle of the trunk and tail. Studies of knockout mice and gene expression analyses have shown that the Notch pathway is crucial in establishing the reiterative pattern of somites. A large-scale screen in zebrafish previously identified five mutants that show abnormalities in somite...
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