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Article

Axin1 Protects Colon Carcinogenesis by an Immune-Mediated Effect

8 Nov 2022

Abstract excerpt

BACKGROUND & AIMS: Axin1 is a negative regulator of wingless-type MMTV integration site family, member 1 (Wnt)/β-catenin signaling with tumor-suppressor function. The Wnt pathway has a critical role in the intestine, both during homeostasis and cancer, but the role of Axin1 remains elusive. METHODS: ) and Axin2-knockout mice. We evaluated the tumor-suppressor function of Axin1 during chemically induced colorectal...

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PMID: 36356835
DOI: 10.1016/j.jcmgh.2022.10.017

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