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Article

Heterozygote advantage of the MTHFR C677T polymorphism on specific cognitive performance in elderly Chinese males without dementia.

Dementia and geriatric cognitive disorders - 1 Jan 2011

Tsai Shih-Jen, Hong Chen-Jee, Yeh Heng-Liang, Liou Ying-Jay, Yang Albert C, Liu Mu-En, Hwang Jen-Ping

Abstract excerpt

AIMS: Aging is associated with cognitive deterioration, and genetic factors are implicated in individual cognitive differences in the aged. The C677T mutation in the 5,10-methylenetetrahydrofolate reductase gene (MTHFR) yields a common thermolabile variant (T) with reduced enzyme activity and consequent elevation of serum homocysteine concentrations. We designed the present study to investigate whether this...

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Identifiers

PMID: 21997345
DOI: 10.1159/000333074

Genes

MTHFR

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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