Article
Asian flush gene variant increases mild cognitive impairment risk: a cross-sectional study of the Yoshinogari Brain MRI Checkup Cohort.
Environmental health and preventive medicine - 1 Jan 2024
Tokiya Mikiko, Hashimoto Manabu, Fukuda Kenji, Kawamoto Kazuhiro, Akao Chiho, Tsuji Mariko, Yakushiji Yusuke, Koike Haruki, Matsumoto Akiko
Abstract excerpt
BACKGROUND: The East Asian-specific genetic diversity, the rs671 variant of aldehyde dehydrogenase 2, causes the "Asian flush" phenomenon following alcohol consumption, resulting in an alcohol avoidance phenotype. The variant is suggested as a risk factor for Alzheimer's disease; however, its association with mild cognitive impairment (MCI), an effective target for secondary prevention of dementia, remains...
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