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Article

High homocysteine and epistasis between MTHFR and APOE: association with cognitive performance in the elderly.

Experimental gerontology - 1 Apr 2016

Polito Letizia, Poloni Tino Emanuele, Vaccaro Roberta, Abbondanza Simona, Mangieri Michela, Davin Annalisa, Villani Simona, Guaita Antonio

Abstract excerpt

High total homocysteine (tHcy) is associated with cognitive impairment in the elderly. The impact of high tHcy on different cognitive domains deserves further investigation, as does the role of the C677T polymorphism of the 5,10 methylenetetrahydrofolate reductase (MTHFR) gene. A cross-sectional analysis of 903 subjects from the population-based "InveCe.Ab" study was performed. The participants had no psychosis...

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Source

Identifiers

PMID: 26774227
DOI: 10.1016/j.exger.2016.01.005

Genes

MTHFR
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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