Article
Methylenetetrahydrofolate reductase 677C>T and methionine synthase 2756A>G mutations: no impact on survival, cognitive functioning, or cognitive decline in nonagenarians.
The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Feb 2007
Bathum Lise, von Bornemann Hjelmborg Jacob, Christiansen Lene, McGue Matt, Jeune Bernard, Christensen Kaare
Abstract excerpt
BACKGROUND: Several reports have shown an association between homocysteine, cognitive functioning, and survival among the oldest-old. Two common polymorphisms in the genes coding for methylenetetrahydrofolate reductase (MTHFR 677C>T) and methionine synthase (MTR 2756A>G) have an impact on plasma homocysteine level. METHODS: We examined the effect of the MTHFR 677C>T and MTR 2756A>G genotypes on baseline cognitive...
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