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Article

Thermolabile methylenetetrahydrofolate reductase gene and the risk of cognitive impairment in those over 85.

Journal of neurology, neurosurgery, and psychiatry - 1 Oct 1999

Gussekloo J, Heijmans B T, Slagboom P E, Lagaay A M, Knook D L, Westendorp R G

Abstract excerpt

OBJECTIVES: Previous reports have shown raised plasma concentrations of homocysteine in older persons with cognitive impairment. This may be caused by environmental and genetic factors. The relation between cognitive function and a common ala/val mutation in the methylenetetrahydrofolate reductase (MTHFR) gene was studied in those over 85. Homozygous carriers of this mutation are characterised by a lifelong...

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Identifiers

PMID: 10486408
DOI: 10.1136/jnnp.67.4.535
PMCID: PMC1736557

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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