Article
Increased variance in germline allele-specific expression of APC associates with colorectal cancer.
Gastroenterology - 1 Jan 2012
Curia Maria Cristina, De Iure Sabrina, De Lellis Laura, Veschi Serena, Mammarella Sandra, White Marquitta J, Bartlett Jacquelaine, Di Iorio Angelo, Amatetti Cristina, Lombardo Marco, Di Gregorio Patrizia, Battista Pasquale, Mariani-Costantini Renato, Williams Scott M, Cama Alessandro
Abstract excerpt
BACKGROUND & AIMS: Germline variations in allele-specific expression (ASE) are associated with highly penetrant familial cancers, but their role in common sporadic cancers is unclear. ASE of adenomatous polyposis coli (APC) is associated with pathogenesis of familial adenomatous polyposis. We investigated whether moderate variations in ASE of APC contribute to common forms of colorectal cancer (CRC). METHODS:...
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