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Article

Alleles of APC modulate the frequency and classes of mutations that lead to colon polyps.

Nature genetics - 1 Dec 1998

Spirio L N, Samowitz W, Robertson J, Robertson M, Burt R W, Leppert M, White R

Abstract excerpt

Most inherited mutant alleles of the adenomatosis polyposis coli gene (APC) cause the appearance of large numbers of colon polyps, the familial polyposis syndrome. (These mutant alleles are designated APCp alleles.) A subset of APC mutations, the attenuated or APC(AP) alleles, predispose to only...

Topics

Adenomatous Polyposis Coli
Adult
Aged
Alleles
Female
Genes, APC
Humans
Loss of Heterozygosity
Male
Middle Aged
Mutation

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 9843214
DOI: 10.1038/3865

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9843214-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Alleles of APC modulate the frequency and classes of mutations that lead to colon polyps.PMID 9843214Read ↗

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Inactivation of germline mutant APC alleles by attenuated somatic mutations: a molecular genetic mechanism for attenuated familial adenomatous polyposis.Semantic proximity Read ↗

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