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Article

Pseudoexons provide a mechanism for allele-specific expression of APC in familial adenomatous polyposis.

Oncotarget - 25 Oct 2016

Nieminen Taina T, Pavicic Walter, Porkka Noora, Kankainen Matti, Järvinen Heikki J, Lepistö Anna, Peltomäki Päivi

Abstract excerpt

Allele-specific expression (ASE) of the Adenomatous Polyposis Coli (APC) gene occurs in up to one-third of families with adenomatous polyposis (FAP) that have screened mutation-negative by conventional techniques. To advance our understanding of the genomic basis of this phenomenon, 54 APC mutation-negative families (21 with classical FAP and 33 with attenuated FAP, AFAP) were investigated. We focused on four...

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Source

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Identifiers

PMID: 27683109
DOI: 10.18632/oncotarget.12206
PMCID: PMC5342583

Genes

APC
FAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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