Article
Exon eight APC mutations account for a disproportionate number of familial adenomatous polyposis families.
Human mutation - 1 Jan 1994
Koorey D J, McCaughan G W, Trent R J, Gallagher N D
Abstract excerpt
The familial adenomatous polyposis gene, APC, has recently been identified. Detection of APC mutations will facilitate genetic screening in family members at risk for this disease. The length of APC makes it impractical to examine the entire coding sequence in each new family encountered. Identification of mutation cluster regions within the gene has therefore become a priority. Initial reports suggested that...
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