Article
Pancreatic ductal adenocarcinoma in hereditary diffuse gastric cancer. A case report.
Human pathology - 1 Mar 2012
Ottenhof Niki A, de Wilde Roeland F, Morsink Folkert H M, de Leng Wendy W J, Ausems Margreet G E M, Morreau Hans, van Hillegersberg Richard, Offerhaus G Johan A, Milne Anya N
Abstract excerpt
Hereditary diffuse gastric cancer is an autosomal dominant cancer syndrome characterized by highly penetrant diffuse gastric cancer. It is caused by germ line mutations in CDH1, encoding the cell-cell adhesion protein E-cadherin. Pancreatic ductal adenocarcinoma is one of the most dismal malignan...
Topics
- Adenocarcinoma
- Antigens, CD
- Cadherins
- Carcinoma, Pancreatic Ductal
- DNA Mutational Analysis
- Fatal Outcome
- Gastrectomy
- Germ-Line Mutation
- Humans
- Male
- Middle Aged
- Neoplasm Recurrence, Local
- Neoplasms, Multiple Primary
- Pancreatic Neoplasms