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Article

A chemical-genetic screen reveals a mechanism of resistance to PI3K inhibitors in cancer.

Nature chemical biology - 25 Sept 2011

Muellner Markus K, Uras Iris Z, Gapp Bianca V, Kerzendorfer Claudia, Smida Michal, Lechtermann Hannelore, Craig-Mueller Nils, Colinge Jacques, Duernberger Gerhard, Nijman Sebastian M B

Abstract excerpt

Linking the molecular aberrations of cancer to drug responses could guide treatment choice and identify new therapeutic applications. However, there has been no systematic approach for analyzing gene-drug interactions in human cells. Here we establish a multiplexed assay to study the cellular fitness of a panel of engineered isogenic cancer cells in response to a collection of drugs, enabling the systematic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Drug Resistance, Neoplasm

Share to Gene Expression Regulation, Neoplastic

Share to Phosphoinositide-3 Kinase Inhibitors

Share to Proto-Oncogene Proteins c-myc

Share to TOR Serine-Threonine Kinases

Source

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Identifiers

PMID: 21946274
DOI: 10.1038/nchembio.695
PMCID: PMC3306898

Genes

MYC
NOTCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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