Article
Design, characterization, and structure of a biologically active single-chain mutant of human IFN-gamma.
Journal of molecular biology - 26 May 2000
Landar A, Curry B, Parker M H, DiGiacomo R, Indelicato S R, Nagabhushan T L, Rizzi G, Walter M R
Abstract excerpt
A mutant form of human interferon-gamma (IFN-gamma SC1) that binds one IFN-gamma receptor alpha chain (IFN-gamma R alpha) has been designed and characterized. IFN-gamma SC1 was derived by linking the two peptide chains of the IFN-gamma dimer by a seven-residue linker and changing His111 in the first chain to an aspartic acid residue. Isothermal titration calorimetry shows that IFN-gamma SC1 forms a 1:1 complex...
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